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Ferrotin Forte® Overview

Iron deficiency anaemia

Iron (Fe) deficiency is probably the most common single nutrient deficiency throughout the world. It is estimated that more than 500 million people throughout the world suffer from severe iron deficiency anaemia.

Treatment options

Iron deficiency anemia is better controlled along with diet rich in iron source and supplementation of external source of Iron formulations. Various iron salts are available for supplementation in the treatment of anaemia. They are:

Ferrous salts

All dietary iron has to be reduced to ferrous form to enter the mucosal cells. Hence bivalent iron salts like ferrous sulfate, fumarate, gluconate, succinate, glutamate and lactate have been preferred over ferric salt preparations.

  • Bioavailability
    These salts have uniform bioavailability. However, the bioavailability decreases markedly in the presence of dietary inhibitors like phytates, oxalates, tannates etc., which are abundantly available in foods.
  • Tolerability
    Despite being efficacious and cheap with good bioavailability, ferrous salts have several disadvantages particularly the high incidence of gastrointestinal side effects (~23 %). Ferrous sulphate has a salty astringent taste which is not palatable for most children.

Ferric salts

Ferric salts have traditionally not been preferred over ferrous salts as the ferric ion first requires reduction to ferrous form in the intestinal lumen and usually this reducing capacity is not enough to reduce doses of iron therapeutically administered. The bio-availability of iron from ferric salts is 3 to 4 times less than that of ferrous sulphate.

The Haemoglobin Enhancer That Makes A Difference

 

is a registered TRADEMARK of Omicron Pharmaceuticals Int.

Chelated Ferrous Bisglycinate (Ferrochel®) in Ferrotin Forte®

  • Absorbed intact
  • Easily absorbed into the mucosal tissue
  • Highest bioabsorption
  • High bioavailability even in presence of phytates, tannates, oxalates etc.
  • Less likely to cause intestinal side effects such as nausea, constipation and bloating
  • Does not interact with multivitamins

L5-Methyltetra-Hydrofolic Acid (Quatrefolic®) in Ferrotin Forte®

  • The fourth generation of folate
  • Better absorbed than the common folic acid
  • Contributes to maternal tissue growth during pregnancy
  • Contributes to normal homocysteine metabolism

The Haemoglobin Enhancer That Makes A Difference

 

is a registered TRADEMARK of Omicron Pharmaceuticals Int.

Ferrous bisglycinate – The haemoglobin enhancer with a difference Ferrotin Forte®

Ferrous bisglycinate consists of one molecule of ferrous iron bound to two molecules of glycine. Ferrous bisglycinate has successfully received GRAS (Generally Recognized as Safe) approval from the US FDA.

Absorption

Following oral administration, ferrous bisglycinate is absorbed intact into the mucosal cells of the intestine, and is subsequently hydrolysed into its iron and glycine components. The iron component of 1 ferrous bisglycinate is metabolised like any other source of iron. The solubility of iron from ferrous bisglycinate is not affected by changes in pH.

Bioavailability

The bioavailability of the ferrous bisglycinate chelate and ferrous sulfate is 90.9% and 26.7%. Ferrous bisglycinate has a relatively high bioavailability in the presence of dietary inhibitors like tannins and oxalates.

Clinical Efficacy

The Haemoglobin Enhancer That Makes A Difference

 

is a registered TRADEMARK of Omicron Pharmaceuticals Int.

Ferrotin Forte® product information

Iron Bisglycinate (Ferrochel®): 28 mg

L-5 Methyltetrahydrofolic Acid (Quatrefolic®): 440 mcg

The Haemoglobin Enhancer That Makes A Difference

 

is a registered TRADEMARK of Omicron Pharmaceuticals Int.

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