Ferrotin Forte® Overview
Iron deficiency anaemia
Iron (Fe) deficiency is probably the most common single nutrient deficiency throughout the world. It is estimated that more than 500 million people throughout the world suffer from severe iron deficiency anaemia.
Treatment options
Iron deficiency anemia is better controlled along with diet rich in iron source and supplementation of external source of Iron formulations. Various iron salts are available for supplementation in the treatment of anaemia. They are:
Ferrous salts
All dietary iron has to be reduced to ferrous form to enter the mucosal cells. Hence bivalent iron salts like ferrous sulfate, fumarate, gluconate, succinate, glutamate and lactate have been preferred over ferric salt preparations.
- Bioavailability
These salts have uniform bioavailability. However, the bioavailability decreases markedly in the presence of dietary inhibitors like phytates, oxalates, tannates etc., which are abundantly available in foods. - Tolerability
Despite being efficacious and cheap with good bioavailability, ferrous salts have several disadvantages particularly the high incidence of gastrointestinal side effects (~23 %). Ferrous sulphate has a salty astringent taste which is not palatable for most children.
Ferric salts
Ferric salts have traditionally not been preferred over ferrous salts as the ferric ion first requires reduction to ferrous form in the intestinal lumen and usually this reducing capacity is not enough to reduce doses of iron therapeutically administered. The bio-availability of iron from ferric salts is 3 to 4 times less than that of ferrous sulphate.
The Haemoglobin Enhancer That Makes A Difference
is a registered TRADEMARK of Omicron Pharmaceuticals Int.
Chelated Ferrous Bisglycinate (Ferrochel®) in Ferrotin Forte®
- Absorbed intact
- Easily absorbed into the mucosal tissue
- Highest bioabsorption
- High bioavailability even in presence of phytates, tannates, oxalates etc.
- Less likely to cause intestinal side effects such as nausea, constipation and bloating
- Does not interact with multivitamins
Lactoferrin in Ferrotin Forte®
- Helps regulate the absorption of iron in the Intestine
- Helps better delivery of iron to the cells
- Significantly increases total serum iron by direct supply of iron through a specific lactoferrin-binding receptor on the intestine
- Contributes to normal homocysteine metabolism
The Haemoglobin Enhancer That Makes A Difference
is a registered TRADEMARK of Omicron Pharmaceuticals Int.
Ferrous bisglycinate – The haemoglobin enhancer with a difference Ferrotin Forte®
Ferrous bisglycinate consists of one molecule of ferrous iron bound to two molecules of glycine. Ferrous bisglycinate has successfully received GRAS (Generally Recognized as Safe) approval from the US FDA.
Absorption
Following oral administration, ferrous bisglycinate is absorbed intact into the mucosal cells of the intestine, and is subsequently hydrolysed into its iron and glycine components. The iron component of 1 ferrous bisglycinate is metabolised like any other source of iron. The solubility of iron from ferrous bisglycinate is not affected by changes in pH.
Bioavailability
The bioavailability of the ferrous bisglycinate chelate and ferrous sulfate is 90.9% and 26.7%. Ferrous bisglycinate has a relatively high bioavailability in the presence of dietary inhibitors like tannins and oxalates.
Clinical Efficacy
The Haemoglobin Enhancer That Makes A Difference
is a registered TRADEMARK of Omicron Pharmaceuticals Int.
Lactoferrin- Makes a difference in Ferrotin Forte®
- Lactoferrin helps regulate the absorption of iron in the intestine and delivery of iron to the cells
- Due to the iron-binding properties, Lactoferrin can enhance intestinal iron absorption and improve hemoglobin production, circulating iron levels, and stored iron levels
- Lactoferrin has been reported as an effective therapy in the treatment of anemia in both pediatrics and adults
- Lactoferrin for low iron levels during pregnancy
Lactoferrin General Benefits
The Haemoglobin Enhancer That Makes A Difference
is a registered TRADEMARK of Omicron Pharmaceuticals Int.
Ferrotin Forte® product information
- Iron Bisglycinate (Ferrochel®): 140 mg (equivalent to 28 mg elemental iron)
- Lactoferrin: 10 mg
The Haemoglobin Enhancer That Makes A Difference
is a registered TRADEMARK of Omicron Pharmaceuticals Int.
